In my opinion, despite the cartoon-y graphics, the PhysX makes these graphics absolutely revolutionary and adds a surprising bit of permanence and realism to an otherwise otherworldly (both in and out of game) experience.
Next I have to note the dialogue. Some find it annoying, I find it to be so awful that it is hilarious! I actually eagerly await Handsome Jack's (the villain) *le sigh* phone calls. I mean, he calls you, while you're fighting through an enemy encampment, to tell you about his diamond pony named Butt Stallion while simultaneously eating stale pretzels, tell ya what folks, he's a keeper!
("Butt Stallion is best pony!")
Next up, gameplay. So, I've been playing through as Salvador the Gunzerker, which is actually pretty excellent once you get the Gunzerking skill. I'm not complaining about regaining 50% health and the ability to use two guns at once for a moment, in fact it's pretty awesome (when I remember to activate it!). Single player is nice because you can pause at will and take your time. Multiplayer is great, too! It works on the same mechanic as the first game so it's quite convenient if you need to help your buddy with something on their game or they need to help you on yours. Having the characters say reassuring things while patching each other up in battle is an excellent touch as well.
The story? Well, the story's pretty straightforward, kill the jerk who tried to kill you, and find the new vault. But really amidst everything else the smaller goals along the way and the way that things are laid out actually make the game feel quite casual, and I really do love that aspect. I'm not in it to kill some dudes, I'm in it to kill some dudes and have fun doing it, preferably with the help of friends!